This article details the structure and function of basophils as well as the diseases and conditions associated with high or low basophils.
What Do Basophils Do?
Basophils are a type of white blood cell, also known as a leukocyte. White blood cells play a role in the body’s immune defense and protect the body against infectious diseases and foreign invaders.
Basophils are part of the innate immune system. This is the immunity you are born with as opposed to immunity you later develop after infection or vaccination.
As part of the innate immune system, basophils do not make you immune to an infection you have had in the past. They are simply among the frontline cells that attack any foreign agent that enters the body.
Basophils are most effective in protecting against bacteria and parasites, including parasites like ticks and worms.
How Basophils Work
Basophils help trigger inflammatory reactions. Inflammation is the body’s natural response to anything that might cause it harm. It is the body’s way of signaling the immune system to heal and repair damaged tissues as well as defend itself against foreign agents.
The granules inside the basophils contain histamine and heparin, among other things. Each has a different role:
Histamine is a vasodilator, meaning that it causes blood vessels to widen. This brings more immune cells to the site of an injury or infection. Heparin is an anticoagulant (blood thinner). It is produced by the body to prevent blood clots from forming at the site of an injury or infection.
Basophils also indirectly attack foreign agents by binding to a type of white blood cell called B-cell lymphocytes. The binding causes B-cells to release antibodies called immunoglobulin E (IgE) into the bloodstream. IgE has strong action against parasites and venoms.
Abnormal Basophil Counts
The composition of white blood cells is measured with a test called a white blood cell (WBC) count, of which basophils account for between 0.5% to 1%. The actual number of basophils is measured with a test called the absolute basophils count (ABC) described in cubic millimeters (mm3).
A normal ABC is between 15 and 50 mm3. When the count is outside of this range, it is considered abnormal. These abnormalities are described as either basophilia (high basophils) or basopenia (low basophils):
Basophilia occurs with an ABC over 50 mm3. Possible causes include allergy, autoimmune diseases (like lupus and rheumatoid arthritis), hemolytic anemia, hypothyroidism, infections (such as chickenpox, influenza, and tuberculosis), inflammatory bowel disease (IBD), leukemia, lymphoma, and myeloproliferative disorders. Basopenia occurs with an ABC under 15 mm3. it can occur with acute infection, chemotherapy, heart attack, hyperthyroidism, pregnancy, radiation therapy, severe allergies (including anaphylaxis), and prolonged steroid use.
Conditions
There are a number of conditions that can cause your basophil counts to fall outside of the normal range.
Chronic Inflammation
Conditions that cause chronic inflammation are associated with basophilia. Some of these conditions include:
Inflammatory bowel disease (IBD)Rheumatoid arthritisPsoriasis
Allergies
An allergy is an abnormal response by the immune system to a substance or event that is otherwise harmless. The histamine released by basophils is one of the main causes of allergy symptoms. When the body is exposed to an allergen (allergy-causing substance), basophils and related cells called mast cells will break open.
The release of histamine causes blood vessels to widen, which causes fluid to leak into surrounding tissues. This can lead to redness and swelling of the skin in the form of rash, hives, or angioedema as well as nasal symptoms and breathing problems as those tissues swell and become inflamed.
Histamine is also involved in itching. It does so by attaching to proteins called H1 receptors in the skin, triggering abnormal sensations in surrounding nerve fibers.
Thyroid Conditions
Both hypothyroidism and hyperthyroidism can affect your basophil levels.
When you have hypothyroidism, your body doesn’t produce enough thyroid hormone. High basophils are associated with hypothyroidism.
Hyperthyroidism is a condition where your body produces too much thyroid hormone. When you have this condition, you may have low basophils.
Leukemia and Lymphoma
Basophilia can also be a feature of certain types of cancers, such as leukemia and lymphoma. Accelerated chronic myeloid leukemia (CML) is often marked by very high basophil levels of 20% or more. People with Hodgkin’s lymphoma may also have elevated basophils.
Summary
Basophils are a type of white blood cell called a granulocyte. As part of the innate immune system, basophils are one of the frontline defenders against diseases, including parasites.
High basophils (basophilia) may be caused by infections, autoimmune diseases, and cancer, while low basophils (basopenia) may be caused by acute infection, severe allergies, medications, and cancer treatments. Basophils also play a role in allergies by releasing an allergy-causing chemical called histamine into the bloodstream.
Allergies, including hay fever and food allergiesInfections, such as chickenpox and tuberculosisHypothyroidism (low thyroid function)Inflammatory diseases, such as inflammatory bowel disease (IBD) and rheumatoid arthritisLymphoma (both Hodgkin lymphoma and non-Hodgkin lymphoma)Myeloproliferative disorders, such as chronic myeloid leukemia (CML), polycythemia vera, and essential thrombocythemia
OvulationUrticaria (hives)AngioedemaHyperthyroidismHypersensitive drug reactions, such as Stevens-Johnson syndromeAnaphylaxis
